Megumi Noda, or "Nodame" is a piano student at Momogaoka College of Music. An extremely talented pianist who wants to be a preschool teacher, she prefers playing by ear rather than reading the music score. She is messy and disorganized, takes baths several days apart and loves to eat, sometimes stealing her friend's lunchbox when it is filled with delicacies.
Shinichi Chiaki is Momogaoka's top student. Born into a musical family, he is talented in piano and violin and has secret ambitions to become a conductor. An arrogant multi-lingual perfectionist who once lived abroad in the music capitals of the world as a young boy (namely Prague), he is trapped in Japan because of his childhood phobia of airplanes and the ocean.
They meet by accident. Nodame quickly falls in love, but it takes much longer for Chiaki to even begin to appreciate Nodame's unusual qualities. Their relationship causes them both to develop and grow. Along the way, they meet some crazy people (like Masumi, Mine, and Stresemann) and make lasting friendships. Because of Nodame, Chiaki gets the opportunity to lead a student orchestra and begins to have a broader appreciation of people's musical abilities. Because of Chiaki, Nodame faces her fears and enters a piano competition. Opportunities open up as both begin taking risks, stretching themselves far more than they ever thought possible.
After graduation, Nodame succeeds in curing Chiaki from his phobia and they both move to Paris where Nodame continues her piano studies at the Conservatoire de Paris while Chiaki starts a professional career as a conductor. In Europe, they encounter new friends and rivals, as well as keep in touch with their friends from Japan.
